20 Jul 2010 . An FDA advisory panel called on the agency to revoke its approval of Roche's Avastin as a breast-cancer treatment after studies failed to .

In a big blow to drug companies seeking to market targeted cancer drugs, a .

17 Aug 2010 . An impending decision by the Food and Drug Administration to rescind its earlier approval of the drug Avastin for women with advanced breast .

20 Jul 2010 . The drug failed to live up to preliminary promise, experts contend.

17 Aug 2010 . To repeal the drug Avastin for treating breast cancer would raise arguments against the health care reforms in the United States and the .

30 Dec 2009 . You may have heard about the drug Avastin, which is used to treat secondary breast cancer (breast cancer that has spread to other sites in .

22 Jul 2010 . Early studies had shown that women with HER-2 negative breast cancer who took Avastin and the chemotherapy drug paclitaxel (Taxol) went .

19 Jul 2010 . US health regulators are questioning whether Avastin is really an effective treatment for breast cancer. A Food & Drug Administration (FDA) .

9 Jul 2010 . The review of Avastin's conditional US approval in first-line metastatic breast cancer later this month by an FDA advisory committee .

21 Jul 2010 . FDA-ODAC Votes To Remove Avastin's Breast Cancer Indication Bevacizumab (Avastin, Genentech) is likely to lose its breast cancer indication, .

16 Aug 2010 . The debate over Avastin, prescribed to about 17500 women with breast cancer a year, has become entangled in the politically explosive .

20 Jul 2010 . An advisory panel has voted 12 to 1 to recommend that the US Food and Drug Administration revoke their approval of the blockbuster cancer .

19 Aug 2010 . Avastin was approved for breast cancer under an FDA program called “accelerated approval” in which the agency provides “conditional” .

20 Jul 2010 . Experts Urge Food and Drug Administration to Remove Approval of Blockbuster Cancer Drug; Studies Fail to Show Benefits.

17 Sep 2010 . Apparently, the FDA is having a tough time making a decision whether to rescind approval for Roche/Genentech's Avastin for use in treating .

By a 12-1 vote, an FDA expert advisory panel found Avastin unhelpful for .

WebMD examines the use of Avastin to treat breast cancer. Does it work? What are the risks? Costs? Find out what you need to know.

Metastatic Breast Cancer (MBC) Avastin is indicated for the treatment of . The effectiveness of Avastin in metastatic breast cancer is based on an .

16 Aug 2010 . Federal regulators are considering taking the highly unusual step of rescinding approval of a drug that patients with advanced breast cancer .

21 Jul 2010 . A Food and Drug Administration advisory committee Tuesday recommended that the agency withdraw its marketing approval of the blockbuster .

20 Jul 2010 . An advisory committee recommended revoking federal approval of the drug as a treatment for breast cancer.

16 Jul 2010 . US government health scientists said Friday that follow-up studies of a Roche breast cancer drug show it failed to slow tumor growth or .

Avastin in combination with paclitaxel, a type of chemotherapy, is approved .

On Tuesday, the FDA Oncologic Drugs Advisory Committee voted 12-1 to recommend that the agency revoke approval of Avastin for the treatment .

19 Jul 2010 . Roche Holding AG's top-seller Avastin may shed $1 billion in annual revenue if US regulators follow a panel recommendation to revoke .

23 Jul 2010 . The drug Avastin gained approval to treat breast cancer from the FDA in 2008. Now, the FDA is questioning the drug's efficacy.

16 Jul 2010 . The Food and Drug Administration questioned the benefit of using Roche Holding AG's top-selling cancer drug, Avastin, in breast cancer.

21 Jul 2010 . The recommendation does not affect the drug's marketing for treatment of four other types of cancer. New trials failed to confirm initial .

20 Jul 2010 . Avastin should generate $6.5 billion in sales this year, with about $1.2 billion coming breast cancer usage, according to Sanford Bernstein .

16 Jul 2010 . Federal health scientists say followup studies of a Roche breast cancer drug show it failed to slow tumour growth or extend patient lives, .

18 Sep 2010 . (Updates with background and FDA statement) The US Food and Drug Administration Friday delayed a decision involving the use of Roche Holding .

19 Jul 2010 . FDA drug reviewers are questioning the benefits of Avastin, a cancer drug by Roche, saying that studies show it does not extend lives of .

by Z Chustecka

18 Jul 2010 . Roche Holding AG's top-selling Avastin didn't slow breast tumors in new studies as much as in earlier tests used to win approval, .

Avastin was recently approved as a treatment for metastatic, advanced breast cancer.

16 Aug 2010 . The latest debate over Roche's Avastin--whether the FDA should yank its approval for breast cancer use--shows how pulling a drug off the .

20 Sep 2010 . The U.S. Food and Drug Administration (FDA) has decided to extend the review of Roche Holding AG's breast cancer medication Avastin by three .

Also: Harvard Med School tightens its rules on faculty-industry involvement .

21 Jul 2010 . According to a Food and Drug Administration (FDA) advisory committee's (The Oncology Drugs Advisory Committee, or ODAC) recommendation this .

3 Sep 2010 . One of the most frustrating aspects of taking care of cancer patients is that in general, with a handful of specific exceptions, .

27 Sep 2010 . That's because in 2008, when the FDA gave “fast track” approval for Avastin in breast cancer that has metastasized—usually to the lungs, .

21 Jul 2010 . The recommendation from the committee does not affect Avastin's current availability for US patients with breast cancer. .

Will Roche hang on to Avastin's breast-cancer indication? That's the .

22 Jul 2010 . In 2008, the FDA granted Avastin accelerated approval for the first-line treatment of metastatic HER2 negative breast cancer. .

20 Jul 2010 . Bevacizumab in the treatment of breast cancer has followed a long, somewhat tortuous course beginning as early as 2005 with an announcement .

17 Sep 2010 . WASHINGTON (Reuters) - US regulators have extended by three months a review of Roche Holding AG's blockbuster drug Avastin in breast cancer, .

by HS Rugo - 2004 - Cited by 77 - Related articles

16 Aug 2010 . The costly biotech drug blocks the growth of blood vessels that feed tumors. In July, a panel of experts voted 12-1 to recommend that FDA .

17 Jul 2010 . The benefit of using the top-selling cancer drug Avastin for breast cancer was questioned by the Food and Drug Administration. .